Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure.
Michael J LanspaMichelle Ng GongDavid A SchoenfeldKathleen Tiffany LeeColin K GrissomPeter C HouAry Serpa-NetoSamuel M BrownTheodore J IwashynaDonald M YealyCatherine L HoughRoy G BrowerCarolyn S CalfeeRobert C HyzyMichael A MatthayRussell R MillerJay S SteingrubB Taylor ThompsonChadwick D MillerTerry P ClemmerGregory W HendeyDavid T HuangKusum S MathewsNida QadirMark Tidswellnull nullPublished in: Annals of the American Thoracic Society (2020)
Use of initial tidal volumes less than 8 ml/kg predicted body weight was common at hospitals participating in the National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury (PETAL) Network. After considering the size and budgetary requirement for a cluster-randomized trial of LTVV versus usual care in acute respiratory failure, the PETAL Network deemed the proposed trial infeasible. A rapid observational study and simulations to model anticipated power may help better design trials.
Keyphrases
- respiratory failure
- body weight
- extracorporeal membrane oxygenation
- mechanical ventilation
- phase iii
- healthcare
- study protocol
- quality improvement
- phase ii
- carbon dioxide
- clinical trial
- lipopolysaccharide induced
- palliative care
- acute respiratory distress syndrome
- heart failure
- open label
- lps induced
- intensive care unit
- atrial fibrillation
- randomized controlled trial
- replacement therapy
- monte carlo