PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells.
Malgorzata BajorAgnieszka Graczyk-JarzynkaKatsiaryna MarhelavaAnna BurdzinskaAngelika MuchowiczAgnieszka GoralAndriy ZhylkoKarolina SoroczynskaKuba ReteckiMarta KrawczykMarta KlopotowskaZofia PilchLeszek PaczekKarl-Johan MalmbergSébastien WälchliMagdalena WiniarskaRadoslaw ZagożdżonPublished in: Journal for immunotherapy of cancer (2022)
In summary, our studies show that CAR-effector cells trigger the expression of PD-L1 on target cells, which in case of PD-L1-CAR results in the unique self-amplification phenomenon. This self-amplifying effect could be responsible for the enhanced cytotoxicity of PD-L1-CAR T cells against both malignant and non-malignant cells and implies extensive caution in introducing PD-L1-CAR strategy into clinical studies.