Gastrointestinal manifestations in patients with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a systematic review with analysis of individual patient data.

P A Skat-RørdamY KayaN QvistTvO HansenT D JensenJ G KarstensenA M Jelsig

Published in: Hereditary cancer in clinical practice (2024)

Patients with a pathogenic variant in the APC promoter 1B region have an increased risk of gastric polyposis and early-onset gastric cancer. However, there is considerable variation in clinical expression and penetrance, which makes decisions on surveillance and the timing of prophylactic gastrectomy challenging.

Keyphrases

early onset
late onset
chronic rhinosinusitis
poor prognosis
public health
dna methylation
squamous cell carcinoma
case report
gene expression
transcription factor
electronic health record
big data
binding protein
locally advanced
long non coding rna
data analysis
deep learning