Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis.

Ning-Sheng LaiHui-Chun YuChien-Hsueh TungKuang-Yung HuangHsien-Bin HuangMing-Chi Lu

Published in: Arthritis research & therapy (2018)

Among the miRNAs regulated by IL-23, expression levels of five miRNAs were increased in T cells from patients with AS. The transfection of miR-29b-1-5p mimic could inhibit the IL-23-mediated STAT3 phosphorylation and might play a role in negative feedback control in the immunopathogenesis of AS.

Keyphrases

ankylosing spondylitis
poor prognosis
disease activity
binding protein
long non coding rna
cell proliferation
transcription factor
systemic lupus erythematosus