P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages.
Judith BockstiegelJonas EngelhardtGünther WeindlPublished in: Cell communication and signaling : CCS (2023)
Our findings suggest a previously unrecognized mechanism of P2X7 receptor mediated IL-1β release and highlight the existence of an NLRP3-independent pathway in human macrophages. Video Abstract.