Orthodontic cell stress modifies proinflammatory cytokine expression in human PDL cells and induces immunomodulatory effects via TLR-4 signaling in vitro.
Jana MarciniakStefan LossdörferIsabel KnaupAsisa BastianRogerio B CraveiroAndreas JägerMichael WolfPublished in: Clinical oral investigations (2019)
These findings hold out the prospect of interfering with the cellular response to mechanical cell stress in order to minimize undesired side effects of orthodontic tooth movement.