Global Survey of Protein Dynamic Properties.

Using tools developed to study the dynamic bioinformatics of proteins, we are able to study the dynamic characteristics of very large numbers of protein sequences simultaneously. We study herein the distribution of protein sequences in a space determined by sequence mobility. It is shown that there are statistically significant differences in mobility distribution between folded sequences of different structural classes and between those and sequences of intrinsically disordered proteins. It is also shown that the several regions of mobility space differ significantly with respect to structural makeup. Helical proteins are shown to have distinctive dynamic characteristics at both extremes of the mobility spectrum.