Quantitative evaluation of factors influencing the 3 Hz repetitive nerve stimulation test in patients with amyotrophic lateral sclerosis.
Jinghong ZhangFei YangMao LiYahui ZhuXusheng HuangPublished in: Muscle & nerve (2024)
In patients with ALS, NMJ safety factor is reduced during re-innervation. Decremental response is affected by multiple factors, which needs to be considered in clinical trials targeting the NMJ in these patients.
Keyphrases
- amyotrophic lateral sclerosis
- clinical trial
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- high frequency
- prognostic factors
- peritoneal dialysis
- high resolution
- randomized controlled trial
- cancer therapy
- open label
- patient reported
- mass spectrometry
- study protocol
- double blind
- placebo controlled