Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.

Mengyang ZhangChangcheng LuoDongxu LinKai Cui Zhong ChenJihong Liu

Published in: Oxidative medicine and cellular longevity (2021)

KLK1 protects prostate from oxidative stress and fibrosis via amplified NO/cGMP signal in aged rats. The decrease of KLK1 expression with aging is laying the groundwork for the application of KLK1 to the treatment of human BPH. The current experimental data showed that the side effects of KLK1 on the prostate cell were not obvious.

Keyphrases

benign prostatic hyperplasia
endothelial cells
prostate cancer
oxidative stress
induced pluripotent stem cells
pluripotent stem cells
lower urinary tract symptoms
nitric oxide
stem cells
mesenchymal stem cells
cell therapy
bone marrow
ischemia reperfusion injury
deep learning
human health
community dwelling