The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors.
Evhy ApryaniUsman AliZi-Ying WangHai-Yun WuXiao-Fang MaoKhalil Ali AhmadXin-Yan LiYong-Xiang WangPublished in: Journal of neuroinflammation (2020)
Our results illustrate that cinobufagin produces mechanical antiallodynia in bone cancer pain through spinal microglial expression of IL-10 and subsequent β-endorphin following activation of α7-nAChRs. Our results also highlight the broad significance of the recently uncovered spinal microglial IL-10/β-endorphin pathway in antinociception.
Keyphrases
- neuropathic pain
- spinal cord
- papillary thyroid
- inflammatory response
- chronic pain
- lipopolysaccharide induced
- lps induced
- squamous cell
- bone mineral density
- pain management
- spinal cord injury
- poor prognosis
- soft tissue
- lymph node metastasis
- diabetic rats
- childhood cancer
- binding protein
- bone loss
- oxidative stress
- long non coding rna
- postoperative pain