von Willebrand factor in experimental malaria-associated acute respiratory distress syndrome.
Sirima KraisinSebastien VerhenneThao-Thy PhamKimberly MartinodClaudia TersteegNele VandeputteHans DeckmynKaren VanhoorelbekePhilippe E Van den SteenSimon F De MeyerPublished in: Journal of thrombosis and haemostasis : JTH (2019)
This study suggests that parasite load together with malarial anemia, rather than alveolar leakage, might contribute to shortened survival in PbNK65-infected Vwf-/- mice. VWF deficiency is associated with early reticulocytosis following PbNK65 infection, which potentially explains the increase in parasite load.
Keyphrases
- plasmodium falciparum
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- mechanical ventilation
- toxoplasma gondii
- chronic kidney disease
- trypanosoma cruzi
- type diabetes
- metabolic syndrome
- adipose tissue
- intensive care unit
- free survival
- replacement therapy
- insulin resistance
- skeletal muscle
- iron deficiency
- smoking cessation