Teratocarcinoma-derived growth factor-1 (Cripto-1) is overexpressed in epithelial odontogenic lesions displaying more aggressive behaviour.

Leorik Pereira da Silva Mara Luana Batista Severo Luiz Arthur Barbosa da Silva Hébel Cavalcanti Galvão Lélia Batista de Souza Márcia Cristina da Costa Miguel

Published in: Oral and maxillofacial surgery (2020)

Cripto-1 is critically important in the progression of several tumours since it is related to significant cell survival and differentiation pathways. The high expression of Cripto-1 in more aggressive odontogenic lesions suggests that this molecule may be involved in the activation of important pathways related to the etiopathogenesis of these lesions.

Keyphrases

growth factor
poor prognosis
long non coding rna