Mediation of the total effect of cystic fibrosis-related diabetes on mortality: A UK Cystic Fibrosis Registry cohort study.

Kamaryn T Tanner Rhian M Daniel Diana BiltonNicholas J SimmondsLinda D Sharples Ruth H Keogh

Published in: Diabetic medicine : a journal of the British Diabetic Association (2022)

There is evidence that pulmonary exacerbations mediate the effect of CFRD on mortality but, as they are estimated to mediate less than one-quarter of the total effect, the mechanism through which CFRD influences survival may involve other factors.

Keyphrases

cystic fibrosis
pseudomonas aeruginosa
lung function
cardiovascular events
type diabetes
cardiovascular disease
risk factors
pulmonary hypertension
chronic obstructive pulmonary disease
glycemic control
cross sectional
free survival
metabolic syndrome
drug induced