High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach.

Chin-Mu Hsu Kung-Chao Chang Tzer-Ming ChuangMan-Ling ChuPei-Wen Lin Hsiao-Sheng Liu Shih-Yu KaoYi-Chang LiuChien-Tzu HuangMin-Hong WangTsung-Jang Yeh Yuh-Ching Gau Jeng-Shiun Du Hui-Ching Wang Shih-Feng ChoChi-En HsiaoYuhsin TsaiSamuel Yien HsiaoLi-Chuan HungChia-Hung YenHui-Hua Hsiao

Published in: Cancers (2023)

G9a overexpression is associated with tumor progression in DLBCL. Niclosamide effectively inhibits DLBCL growth by reducing G9a expression via the cellular autophagy pathway; therefore, G9a is a potential molecular target for the development of therapeutic strategies for DLBCL.

Keyphrases

diffuse large b cell lymphoma
poor prognosis
cell death
endoplasmic reticulum stress
long non coding rna
oxidative stress
signaling pathway
cell proliferation
binding protein