Single-cell transcriptomic analysis reveals tumor cell heterogeneity and immune microenvironment features of pituitary neuroendocrine tumors.

Nan YanWeiyan XieDongfang WangQiuyue FangJing GuoYiyuan ChenXinqi LiLei GongJialin WangWenbo GuoXuegong ZhangYazhuo ZhangJin GuChuzhong Li

Published in: Genome medicine (2024)

Our data and analysis manifested the basic cell types in the normal pituitary and inherent heterogeneity of PitNETs, identified several features of the tumor immune microenvironments, and found a novel epithelial cell sub-population with aggressive signatures across all the studied cases.

Keyphrases

single cell
rna seq
neuroendocrine tumors
high throughput
stem cells
cell therapy
electronic health record
gene expression
mesenchymal stem cells
growth hormone
big data
dna methylation