Association of carbamylated high-density lipoprotein with coronary artery disease in type 2 diabetes mellitus: carbamylated high-density lipoprotein of patients promotes monocyte adhesion.
Zhongli ChenSong DingYan Ping WangLiang ChenJing Yan MaoYing YangJia Teng SunZhongli ChenPublished in: Journal of translational medicine (2020)
Our study identified elevated carbamylation modification of HDL from T2DM patients, especially in those with concomitant CAD. We also evidenced that C-HDL enhanced monocyte to endothelial cell adhesion, indicating a potential pro-atherogenic role of C-HDL in atherosclerosis among T2DM patients. Trial registration https://register.clinicaltrials.gov , NCT04390711 Registered on 14 May 2020; Retrospectively registered.
Keyphrases
- high density
- coronary artery disease
- ejection fraction
- newly diagnosed
- prognostic factors
- clinical trial
- randomized controlled trial
- dendritic cells
- endothelial cells
- type diabetes
- escherichia coli
- cell adhesion
- adipose tissue
- patient reported outcomes
- study protocol
- cystic fibrosis
- cardiovascular events
- patient reported
- insulin resistance
- double blind
- human health