Regulatory function of interferon-inducible 44-like for hepatitis B virus covalently closed circular DNA in primary human hepatocytes.
Takuto NosakaTatsushi NaitoYosuke MurataHidetaka MatsudaMasahiro OhtaniKatsushi HiramatsuTsutomu NishizawaHiroaki OkamotoYasunari NakamotoPublished in: Hepatology research : the official journal of the Japan Society of Hepatology (2021)
Using the in vitro HBV infection system, an IFN-inducible molecule, IFI44L, associated with cccDNA amplification, was identified. These results suggest an innovative molecular strategy for the regulation of HBV cccDNA by controlling a novel host factor, IFI44L.