Are gene polymorphisms related to adverse events of methotrexate in patients with rheumatoid arthritis? A retrospective cohort study based on an updated meta-analysis.

Jing HuangHuizhen FanQi QiuKunpeng LiuShuang LvJiang LiHui YangXiaoming ShuYuan XuXiangchen LuCheng LuYunnan ZhangCheng Xiao

Published in: Therapeutic advances in chronic disease (2020)

Evidence-based results suggest that the MTHFR 677C>T(rs1801133), ATIC 347C>G(rs2372536), RFC-1 80G>A (rs1051266), ABCB1 3435C>T(rs1045642) polymorphisms are associated with MTX-related toxicity. Larger and more stringent study designs may provide more accurate findings for the effects of these SNPs on MTX-related toxicity, and larger sample-size studies of the Chinese Han population should be conducted for further validation.

Keyphrases

systematic review
oxidative stress
randomized controlled trial
gene expression
high dose
meta analyses
mass spectrometry
drug induced
genome wide association