Prestin in Human Perilymph, Cerebrospinal Fluid, and Blood as a Biomarker for Hearing Loss.

Anselm Joseph Gadenstaetter Paul Emmerich Krumpoeck Alice Barbara AuingerErdem YildizAldine TuChristian MatulaChristoph Arnoldner Lukas David Landegger

Published in: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2024)

This study's findings highlight the volatile nature of prestin levels and provide the first insights into this potential biomarker's concentrations in body fluids apart from blood. Future investigations should comprehensively assess human prestin levels with different etiologies of SNHL, prestin's natural homeostasis and systemic circulation, and its temporal dynamics after cochlear trauma. Finally, clinically approved detection kits for prestin are urgently required prior to considering a potential translational implementation of this diagnostic technique.

Keyphrases

endothelial cells
hearing loss
cerebrospinal fluid
induced pluripotent stem cells
pluripotent stem cells
primary care
quality improvement
mass spectrometry
label free
sensitive detection
drug administration
tandem mass spectrometry