Phase II Trial of Nelipepimut-S Peptide Vaccine in Women with Ductal Carcinoma In Situ.
Anne E O'SheaG Travis CliftonNa QiaoBrandy M Heckman-StoddardMalgorzata WojtowiczEileen DimondIsabelle BedrosianDiane WeberJudy E GarberAlexander HusbandRicardo Garcia PastorelloJiun-Kae Jack LeeMike HernandezDiane D LiuLana A VornikPowel H BrownGheath Al-AtrashGeorge E PeoplesElizabeth A MittendorfPublished in: Cancer prevention research (Philadelphia, Pa.) (2023)
This trial showed that vaccination of patients with HLA-A2-positive DCIS with NeuVax in the preoperative setting can induce a sustained antigen-specific T-cell response. This provides proof of principle that vaccination in the preoperative or adjuvant setting may stimulate an adaptive immune response that could potentially prevent disease recurrence.