Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape.
Ashley L CookSurojit SurLaura DobbynEvangeline WatsonJoshua D CohenBlair PtakBum Seok LeeSuman PaulEmily HsiueMaria PopoliBert VogelsteinNickolas PapadopoulosChetan BettegowdaKathy GabrielsonShibin ZhouKenneth W KinzlerNicolas WyhsPublished in: bioRxiv : the preprint server for biology (2024)
activity increases the expression of T-cell targetable cancer neoantigens resulting from truncating mutations.