Prevalence and Correlations of Gastrointestinal Symptoms with Endoscopic and Histologic Mucosal Healing in Crohn's Disease.

To characterize the associations between clinical disease activity with endoscopic and histologic (endo-histologic) mucosal healing in Crohn's disease (CD), we performed a secondary analysis of prospectively collected data on 424 ileocolonoscopies from 258 unique adults at a tertiary referral center from 2014-2021. One-third (34%, 25/73) of patients in endoscopic-histologic remission reported gastrointestinal (GI) symptoms. The 2-item patient-reported outcome measure (PRO-2) for abdominal pain and stool frequency correlated weakly with endoscopic (Simple Endoscopic Score for Crohn's Disease; r =0.17, 95% CI 0.08-0.26, p=0.0003) and histologic disease activity (Global Histologic Disease Activity Score; r =0.14, 95% CI 0.03-0.24, p=0.015). Overall, GI symptoms correlate poorly with endo-histologic disease activity.