Comparison of Nimodipine Formulations and Administration Techniques via Enteral Feeding Tubes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Multicenter Retrospective Cohort Study.
Sherif Hanafy MahmoudFatma R HefnyNicholas G PanosLaura DelucillaZinquon NganMarc M PerreaultLeslie A HamiltonAnthony Shaun RowePamela L BuschurJocelyn Owusu-GuhaSulaiman AlmohaishMelissa SandlerMichael J ArmahizerMegan E BarraAaron M CookColleen A BartholTrager D HintzeAnna CantinJessica TraegerJoseph R BlunckJustin ShewmakerSarah V BurgessKristin KauppCaitlin S BrownSarah L ClarkErin D WieruszewskiEljim P TesoroAbdalla A AmmarMahmoud A AmmarMandy J BinningStanislav NaydinNeal FoxDavid M PetersLeana N MahmoudShaun P KeeganGretchen M BrophyPublished in: Pharmacotherapy (2023)
Our findings suggest that enteral nimodipine formulation and administration techniques might not be equivalent. This could be attributed to excipient differences, inconsistency and inaccuracy in medication administration, and altered nimodipine bioavailability. Further studies are needed.