The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice.

Sharon Ann BarrettoFrederic LasserreMarine HuilletMarion RégnierArnaud PolizziYannick LippiAnne FougeratElodie PersonSandrine BruelColette BétoulièresClaire NayliesCéline LukowiczSarra SmatiLaurence GuzylackMaïwenn OlierVassilia ThéodorouLaila Mselli-LakhalDaniel ZalkoWalter WahliNicolas LoiseauLaurence Gamet-PayrastreHervé GuillouSandrine Ellero-Simatos

Published in: Microbiome (2021)

These findings identify PXR as a hepatic effector of microbiota-derived signals that regulate the host's sexually dimorphic lipid and xenobiotic metabolisms in the liver. Thus, our results reveal a potential new mechanism for unexpected drug-drug or food-drug interactions. Video abstract.

Keyphrases

fatty acid
human health
adverse drug
regulatory t cells
dendritic cells
single cell
genome wide
type diabetes
emergency department
gene expression
immune response
binding protein