Increased FNDC5/IRISIN protein expression in breast cancer tissue is associated with obesity in postmenopausal women.
María Elena TejedaPatricia CantoAlberto Tenorio-TorresLetica Orozco-ArguellesRamón Mauricio Coral-VázquezAlejandro Zentella-DehesaMarcela Leal-GarcíaClaudia Cecilia Vega-GarcíaVerónica Bautista-PiñaJuan Pablo MéndezPublished in: Journal of clinical pathology (2021)
Our results confirm that women with breast cancer and obesity exhibit an increased irisin expression in their tumorous tissue compared with women with breast cancer and normal BMI. Likewise, in vitro breast cancer cell lines have the capacity to synthesise and express FNDC5/irisin, without any extracellular stimuli, however the microenvironment surrounding these cells in vivo participates in its regulation.
Keyphrases
- postmenopausal women
- weight gain
- insulin resistance
- bone mineral density
- metabolic syndrome
- weight loss
- type diabetes
- high fat diet induced
- induced apoptosis
- poor prognosis
- body mass index
- stem cells
- cell cycle arrest
- adipose tissue
- endoplasmic reticulum stress
- cell death
- cell proliferation
- long non coding rna
- physical activity
- binding protein