Leukoencephalopathy with transient splenial lesions related to 5-fluorouracil or capecitabine.
Valentine PerrainKevin BihanFlavie BompaireCaroline HouillierFanny JomierDelphine LeclercqSandrine CombretJulien MahéDamien RicardGiulia BerzeroDimitri PsimarasPublished in: European journal of neurology (2021)
5-FU and capecitabine might be responsible for acute leukoencephalopathies with transient splenial lesions that are generally reversible upon drug discontinuation. Resuming the agent responsible for toxicity might be feasible in selected cases, after having excluded dihydropyrimidine dehydrogenase deficiency, if expected benefits outweigh the risks.
Keyphrases
- cerebral ischemia
- phase ii study
- drug induced
- locally advanced
- liver failure
- metastatic breast cancer
- metastatic colorectal cancer
- oxidative stress
- respiratory failure
- squamous cell carcinoma
- human health
- aortic dissection
- emergency department
- subarachnoid hemorrhage
- clinical trial
- radiation therapy
- adverse drug
- rectal cancer
- intensive care unit
- brain injury
- randomized controlled trial
- hepatitis b virus
- replacement therapy
- risk assessment
- extracorporeal membrane oxygenation
- smoking cessation
- acute respiratory distress syndrome
- mechanical ventilation