Modeling oxidative injury response in human kidney organoids.

Aneta PrzepiorskiThitinee VanichapolEugenel B EspirituAmanda E CrunkEmily ParaskyMichael D McDanielsDave R EmletRyan SalisburyCassandra L HappLawrence A VernettiMatthew L MacDonaldJohn A KellumThomas R KleymanCatherine J BatyAlan J DavidsonNeil A Hukriede

Published in: Stem cell research & therapy (2022)

This work establishes a hemin-induced model of kidney organoid injury. This platform provides a new tool to study the injury and repair response pathways in human kidney tissue and will assist in the development of new therapeutics.

Keyphrases

endothelial cells
induced pluripotent stem cells
high glucose
pluripotent stem cells
small molecule
oxidative stress