The genomics and epigenetics of olfactory neuroblastoma: A systematic review.

Raman Preet KaurEvgeny IzumchenkoDukagjin M BlakajNikol MladkovaMatt LechnerThomas L BeaumontCharalampos S FloudasGary L GalliaNyall R London

Published in: Laryngoscope investigative otolaryngology (2021)

The rare character of ONB has limited the sample size available for cytogenetic, genomic, and epigenetic studies and contributes to the limitations of this systematic review. Comprehensive genomic and epigenomic studies with larger cohorts are warranted to validate the initial reports summarized in this review and to identify potential therapeutic targets for ONB.

Keyphrases

systematic review
case control
copy number
meta analyses
gene expression
single cell
randomized controlled trial
genome wide