Effects of Metformin Added to Insulin in Adolescents with Type 1 Diabetes: An Exploratory Crossover Randomized Trial.

Daizhi Yang Jianping Weng Hongrong Deng Xubin Yang Sihui Luo Xueying Zheng Jing Lv Wen Liang Mengjie Hong Zekai Wu Bin Yao Jian-Ping Weng Wen Xu

Published in: Journal of diabetes research (2020)

Metformin added to insulin did not improve metabolic control or glucose variability in lean/normal-weight adolescents with type 1 diabetes. However, metformin added to insulin significantly increased heart rate variability, suggesting that metformin might improve cardiovascular autonomic function in this population.

Keyphrases

heart rate variability
type diabetes
heart rate
physical activity
young adults
glycemic control
body mass index
open label
randomized controlled trial
clinical trial
blood glucose
weight loss
blood pressure
body weight
adipose tissue
weight gain
bone mineral density
postmenopausal women