Development of a novel method to measure bone marrow fat fraction in older women using high-resolution peripheral quantitative computed tomography.

Alison FlehrJulius KällgårdJennifer AlvénKerstin LagerstrandEvin PapaliniMichael WheelerLiesbeth VandenputFredrik KahlKristian F AxelssonDaniel SundhRaghunath Shirish MysoreMattias Lorentzon

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2022)

The novel HR-pQCT method, developed to estimate BMAT, was able to explain a substantial part of the variation in the bone marrow fat fraction and can be used in future studies investigating the role of BMAT in osteoporosis and fracture prediction.

Keyphrases

bone marrow
high resolution
computed tomography
mesenchymal stem cells
adipose tissue
postmenopausal women
positron emission tomography
fatty acid
magnetic resonance imaging
bone mineral density
mass spectrometry
body composition
contrast enhanced
image quality
pet ct
tandem mass spectrometry
liquid chromatography