Effectiveness of cardiac palliative surgery for trisomy 18 patients with increased pulmonary blood flow.
Akari TakaiMasaaki YamagishiKazuyuki IkedaAtsuya SugimotoEisuke IchiseYoshinobu MaedaSatoshi TeramukaiTatsuji HasegawaShinichiro OdaTomoko IeharaPublished in: American journal of medical genetics. Part A (2023)
Congenital heart disease (CHD) is common among patients with trisomy 18 (T18), but cardiac surgery has been rarely indicated for T18 patients due to their short life span. Although the therapeutic effects of aggressive interventions were recently demonstrated for T18 patients, the subjects and factors examined varied, resulting in inconsistent findings. Therefore, the effects of cardiac surgery for T18 remain unclear. We herein investigated the outcomes of cardiac palliative surgery for CHD with increased pulmonary blood flow in T18 patients. 27 patients were examined: 13 (48.1%) underwent cardiac palliative surgery and 14 (51.9%) did not. Median survival times in the no-surgery and surgery groups were 223.0 days (95% confidence interval [CI]: 46-361 days) and 723.0 days (95% CI: 360-1447 days), respectively. The number of patients with pulmonary hypertension significantly differed between the two groups (5 of 14 in the no-surgery group and 0 in the surgery group). Five of 14 patients in the no-surgery group and 10 of 13 in the surgery group were discharged to home care (odds ratio: 10.8 [95% CI: 1.07-110.0]). Therefore, cardiac palliative surgery may be used to treat CHD with increased pulmonary blood flow in T18 patients.
Keyphrases
- minimally invasive
- end stage renal disease
- blood flow
- pulmonary hypertension
- coronary artery bypass
- ejection fraction
- newly diagnosed
- cardiac surgery
- chronic kidney disease
- peritoneal dialysis
- randomized controlled trial
- prognostic factors
- physical activity
- systematic review
- left ventricular
- palliative care
- coronary artery disease
- atrial fibrillation
- metabolic syndrome
- coronary artery
- insulin resistance
- acute coronary syndrome
- weight loss
- patient reported