Structural brain heterogeneity underlying symptomatic and asymptomatic genetic dystonia: a multimodal MRI study.
Aleksandra TomićElisabetta SarassoSilvia BasaiaNataša Dragašević-MiskovićMarina SvetelVladimir S KostićMassimo FilippiFederica AgostaPublished in: Journal of neurology (2023)
DYT genes phenotypic expression is associated with alterations of both motor and extra-motor WM and GM regions. Asymptomatic genetic status is characterized by a very subtle affection of the WM motor pathway, together with an increased cortical thickness of higher-order frontal regions that might interfere with phenotypic presentation and disease manifestation.
Keyphrases
- genome wide
- poor prognosis
- magnetic resonance imaging
- early onset
- white matter
- contrast enhanced
- working memory
- pain management
- single cell
- optical coherence tomography
- resting state
- multiple sclerosis
- gene expression
- case report
- diffusion weighted imaging
- magnetic resonance
- binding protein
- transcription factor
- genome wide identification