Characteristics of clinical trials in rare vs. common diseases: A register-based Latvian study.
Konstantins LogvissDainis KrievinsSanta PurvinaPublished in: PloS one (2018)
The current study confirms that clinical trials in rare diseases vary from those in non-rare conditions, with notable differences in enrollment, randomization, masking, and the use of active comparators. However, we found no significant difference in trial duration and the use of overall survival as a primary endpoint.