Current Status of 68 Ga-Pentixafor in Solid Tumours.
Bawinile HadebeMachaba Michael SathekgeColleen AldousMariza VorsterPublished in: Diagnostics (Basel, Switzerland) (2022)
Chemokine receptor CXCR4 is overexpressed in neoplasms and its expression is related to tumour invasion, metastasis and aggressiveness. 68 Ga-Pentixafor is used to non-invasively image the expression of CXCR4 in tumours and has been widely used in haematological malignancies. Recent evidence shows that therapies targeting CXCR4 can increase the chemosensitivity of the tumour as well as inhibit tumour metastasis and aggressiveness. 68 Ga-Pentixafor has shown promise as an elegant radiotracer to aid in the selection of patients whose tumours demonstrate CXCR4 overexpression and who therefore may benefit from novel therapies targeting CXCR4. In addition, its therapeutic partners 177 Lu- and 90 Y-Pentixather have been investigated in the treatment of patients with advanced haematological malignancies, and initial studies have shown a good treatment response in metabolically active lesions. 68 Ga-Pentixafor in solid tumours complements 18 F-FDG by providing prognostic information and selecting patients who may benefit from therapies targeting CXCR4. This review summarises the available literature on the potential applications of 68 Ga-Pentixafor in solid tumours.
Keyphrases
- pet ct
- cell migration
- poor prognosis
- end stage renal disease
- positron emission tomography
- cancer therapy
- systematic review
- current status
- ejection fraction
- binding protein
- newly diagnosed
- chronic kidney disease
- pet imaging
- cell proliferation
- drug delivery
- transcription factor
- peritoneal dialysis
- long non coding rna
- climate change
- combination therapy
- mass spectrometry