Effect of proton pump inhibitors on voriconazole concentrations in Chinese patients with malignant hematological diseases.

Qi HuangQiong LiuTao YinLin HuHanjun DingShao LiuYue-Ping Jiang

Published in: European journal of clinical pharmacology (2020)

In conclusion, our retrospective data analysis and molecular docking simulations results indicate that LAN and OME interact with VOR via CYP2C19 and CYP3A4 to increase VOR plasma concentrations. This study helps with selection of PPIs in Chinese patients with malignant hematological cancer administered VOR.

Keyphrases

molecular docking
data analysis
molecular dynamics simulations
papillary thyroid
squamous cell
cross sectional
molecular dynamics
squamous cell carcinoma
lymph node metastasis
monte carlo