Cost-effectiveness of a lifestyle modification program in long-term survivors of hemopoietic stem cell transplantation.
Lan GaoMarj MoodieVictoria BrownSharon AveryPublished in: Clinical transplantation (2017)
To evaluate the cost-effectiveness of a lifestyle modification program targeting long-term survivors of hematological malignancy treated with hemopoietic stem cell transplantation, a multistate life table Markov model was used to calculate health outcomes for both the intervention and no intervention. Cost per health-adjusted life year (HALY) saved was reported for four scenarios: all participants with/without standard weight regain, and participants who at baseline were overweight with/without standard weight regain. The program recruited 53 participants and was associated with reductions in body weight of 2.2 kg and BMI 0.8 units on intervention completion (12 months) at a cost of $1233/participant. These adipose reductions were sustained and remained significant at 24 months. The incremental cost-effectiveness ratios varied from $118 418 per HALY to dominant, depending on the weight regain assumption. The program may be cost-effective in transplant survivors, with the results most sensitive to the weight regain assumption and intervention cost.
Keyphrases
- stem cell transplantation
- weight loss
- body weight
- physical activity
- gastric bypass
- randomized controlled trial
- weight gain
- body mass index
- high dose
- quality improvement
- bariatric surgery
- young adults
- roux en y gastric bypass
- metabolic syndrome
- healthcare
- insulin resistance
- adipose tissue
- skeletal muscle
- cancer therapy
- risk assessment
- human health