Decreased phototoxicity of photodynamic therapy by Cx32/Cx26-composed GJIC: A "Good Samaritan" effect.

Deng-Pan WuChun-Hui DingLi-Ru BaiYan ZhouSi-Man YangFan ZhangJin-Lan Huang

Published in: Lasers in surgery and medicine (2019)

The present study provides a cautionary note that for tumors expressing Cx32/Cx26, the presence of Cx32/Cx26-composed GJIC may cause the resistance of tumor cells to PDT. Oppositely, treatment strategies designed to downregulate the expression of Cx32/Cx26 or restrain the function of Cx32/Cx26-mediated GJIC may increase the sensitivity of malignant cell to PDT. Lasers Surg. Med. 51:301-308, 2019. © 2019 Wiley Periodicals, Inc.

Keyphrases

photodynamic therapy
poor prognosis
stem cells
single cell
bone marrow
long non coding rna