Defining gestational thyroid dysfunction through modified non-pregnancy reference intervals: an individual participant meta-analysis.
Joris A J OsingaScott M NelsonJohn P WalshGhalia AshoorGlenn E PalomakiAbel López-BermejoJudit BassolsAshraf AminorroayaMaarten A C BroerenLiangmiao ChenXuemian LuSuzanne J BrownFlora VeltriKun HuangTuija MännistöMarina VafeiadiPeter N TaylorFang-Biao TaoLida ChatziMaryam KianpourEila SuvantoElena N GrinevaKypros H NicolaidesMary E D'AltonKris G PoppeErik AlexanderUlla Feldt-RasmussenSofie BliddalPolina V PopovaLayal ChakerW Edward VisserRobin P PeetersArash DerakhshanTanja G M VrijkotteVictor J M PopTim I M KorevaarPublished in: The Journal of clinical endocrinology and metabolism (2024)
We could not identify modifications of non-pregnancy TSH and FT4 reference intervals that would enable centers to adequately approximate trimester-specific reference intervals. Future efforts should be turned towards studying the meaningfulness of trimester-specific reference intervals and risk-based decision limits.