Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways.
Arshad Husain RahmaniAhmad Abdulaziz A AlmatroudiKhaled S AllemailemHajed Obaid A AlharbiWanian M AlwanianBasmah Awwadh AlhunayhaniMohammad AlgahtaniAbdulrahman TheyabNahlah Makki AlmansourAhmed N AlgefarySolaiman Saleh Ali AldeghaimAmjad Ali KhanPublished in: Biomedicines (2023)
Cancer is a major public health concern worldwide in terms of mortality. The exact reason behind the development of cancer is not understood clearly, but it is evidenced that alcohol consumption, radiation, and exposure to chemicals are main players in this pathogenesis. The current mode of treatments such as surgery, chemotherapy, and radiotherapy are effective, but, still, cancer is a major problem leading to death and other side effects. However, safer and effective treatment modules are needed to overcome the adverse effects of current treatment modules. In this regard, natural compounds have been recognized to ameliorate diseases by exerting anti-inflammatory, anti-oxidative, and anti-tumor potential through several mechanisms. Mangiferin, a xanthone C-glucoside, is found in several plant species including Mangifera indica (mango), and its role in disease prevention has been confirmed through its antioxidant and anti-inflammatory properties. Furthermore, its anti-cancer-potential mechanism has been designated through modulation of cell signaling pathways such as inflammation, angiogenesis, PI3K/AKT, apoptosis, and cell cycle. This article extensively reviews the anticancer potential of mangiferin in different cancers through the modulation of cell signaling pathways. Moreover, the synergistic effects of this compound with some commonly used anti-cancer drugs against different cancer cells are discussed. More clinical trials should be performed to reconnoiter the anti-cancer potential of this compound in human cancer treatment. Further, understanding of mechanisms of action and the safety level of this compound can help to manage diseases, including cancer.
Keyphrases
- papillary thyroid
- pi k akt
- signaling pathway
- cell cycle
- anti inflammatory
- public health
- squamous cell
- cell proliferation
- clinical trial
- oxidative stress
- cell cycle arrest
- alcohol consumption
- emergency department
- human health
- minimally invasive
- randomized controlled trial
- type diabetes
- stem cells
- cell death
- radiation therapy
- risk assessment
- cardiovascular disease
- young adults
- multidrug resistant
- locally advanced
- atrial fibrillation
- coronary artery bypass
- molecular dynamics
- rectal cancer
- acute coronary syndrome
- radiation induced
- climate change
- density functional theory
- replacement therapy
- phase iii
- adverse drug