A comparison of meta-analytic methods for synthesizing evidence from explanatory and pragmatic trials.

Tolulope T SajobiGuowei LiOluwagbohunmi AwosogaMeng WangBijoy K MenonMichael D HillLehana Thabane

Published in: Systematic reviews (2018)

In addition to the original intent of PRECIS-2 tool of aiding researchers in their choice of trial design, PRECIS-2 tool is useful for explaining between study variations in systematic review and meta-analysis of published trials. We recommend that researchers adopt mixture meta-regression methods when synthesizing evidence from explanatory and pragmatic trials.

Keyphrases

systematic review
study protocol
meta analyses
clinical trial
randomized controlled trial
phase iii
phase ii