Topical Diclofenac for Prevention of Capecitabine-Associated Hand-Foot Syndrome: A Double-Blind Randomized Controlled Trial.

Akhil Santhosh Vinod Sharma Sameer Bakhshi Akash Jha Vinod Sharma Prabhat Singh Malik Raja Pramanik Ajay Gogia Chandra Prakash Prasad Tushar SehgalSneha GundArundhathi DevWinson Y CheungR M PandeySaran KumarIshaan GuptaAtul Batranull null

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)

Topical diclofenac prevented HFS in patients receiving capecitabine. This trial supports the use of topical diclofenac to prevent capecitabine-associated HFS.

Keyphrases

phase iii
randomized controlled trial
phase ii study
study protocol
locally advanced
metastatic breast cancer
wound healing
metastatic colorectal cancer
open label
clinical trial
case report
systematic review
placebo controlled