EGF stimulates human trophoblast cell invasion by downregulating ID3-mediated KISS1 expression.

Lanlan FangYibo GaoZhen WangYuxi LiYang YanZe WuJung-Chien ChengYing-Pu Sun

Published in: Cell communication and signaling : CCS (2021)

This study demonstrates that downregulation of EGF can lead to poor trophoblast cell invasion by increasing KISS1 expression which subsequently contributes to the pathogenesis of PE. Video Abstract.

Keyphrases

poor prognosis
endothelial cells
growth factor
cell proliferation
binding protein
signaling pathway
induced pluripotent stem cells