Evaluation of antiseizure drug efficacy and tolerability in the rat lamotrigine-resistant amygdala kindling model.

Cameron S MetcalfJennifer HuffKyle E ThomsonKristina JohnsonSharon F EdwardsKaren S Wilcox

Published in: Epilepsia open (2019)

These results strengthen the conclusion that the lamotrigine-resistant amygdala kindling model demonstrates pharmacoresistance to certain ASDs, including, but not limited to, sodium channel blockers, and supports the utility of the model for helping to identify compounds with potential efficacy against pharmacoresistant seizures.

Keyphrases

functional connectivity
oxidative stress
resting state
randomized controlled trial
emergency department
clinical trial
open label
risk assessment
climate change