Antimicrobial Mechanism of Hydroquinone.
Changyang MaNan HeYingying ZhaoDandan XiaJinfeng WeiWen-Yi KangPublished in: Applied biochemistry and biotechnology (2019)
With growing concern about the possible risks and side effects of antibiotic drugs, more and more natural products with antibacterial activity are studied as the substitutes. In this paper, the antibacterial activity of hydroquinone and arbutin in Ainsliaea bonatii was investigated, which both displayed relatively strong antibacterial activity against Staphylococcus aureus (SA), methicillin-resistant S. aureus (MRSA), and extended spectrum β-lactamase S. aureus (ESBL-SA). The antibacterial mechanism of hydroquinone had been explored by scanning electron microscopy (SEM), alkaline phosphatase (AKP), and bacterial extracellular protein leakage. Results showed that hydroquinone could destroy the bacterial cell wall and membrane, increase permeability, lead leakage of intracellular substance affect synthesis of protein, and influence expression of genes.
Keyphrases
- staphylococcus aureus
- electron microscopy
- silver nanoparticles
- cell wall
- methicillin resistant staphylococcus aureus
- escherichia coli
- biofilm formation
- binding protein
- poor prognosis
- klebsiella pneumoniae
- protein protein
- genome wide
- multidrug resistant
- endothelial cells
- small molecule
- human health
- genome wide identification
- reactive oxygen species
- gene expression
- anti inflammatory
- gram negative
- wound healing
- pseudomonas aeruginosa
- bioinformatics analysis
- transcription factor