Overexpression of NgBR inhibits high-fat diet-induced atherosclerosis in ApoE-deficiency mice.
Ke GongMengyao WangDandan WangYongyao GaoLikun MaXiaoxiao YangXinran ZhuShasha ChenMengxue ZhangHuaxin LiWenquan HuQing Robert MiaoYasuko IwakiriChenzhong LiaoYajun DuanJihong HanPublished in: Hepatology communications (2023)
Taken together, our study demonstrates that overexpression of NgBR enhanced cholesterol metabolism and inhibited cholesterol/fatty acid synthesis to reduce hyperlipidemia, and reduced vascular inflammation, thereby inhibiting atherosclerosis in ApoE-/- mice. Our study indicates that NgBR might be a potential target for atherosclerosis treatment.