Mucosal Microbiome Disruption in Acute Laryngeal Injury Following Intubation.
Ruth J DavisMeghan H ShiltsBritton A StricklandSeesandra V RajagopalaSuman R DasChristopher T WoottenAlexander GelbardPublished in: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2023)
The objective of this study was to characterize mucosal microbial shifts in patients with acute laryngeal injury (ALgI) after intubation. This cross-sectional study included 20 patients with ALgI who underwent early endoscopic intervention with tissue culture, 20 patients with idiopathic subglottic stenosis (iSGS) who underwent tissue culture during the routine endoscopic intervention, and 3 control patients who underwent mucosal swab culture. 70% of the ALgI patients had a positive culture compared to 5% of the iSGS patients and none of the controls. The most identified microbes isolated from ALgI patients included Staphylococcus species in 30% and Streptococcus species in 25%. The high rate of pathologic bacterial infiltration into postintubation laryngeal wounds supports efforts to reduce bacterial colonization of endotracheal tubes and highlights the role of culture-directed antibiotic therapy as a part of early intervention to improve outcomes for patients with ALgI.
Keyphrases
- peritoneal dialysis
- end stage renal disease
- randomized controlled trial
- ejection fraction
- squamous cell carcinoma
- staphylococcus aureus
- microbial community
- escherichia coli
- mesenchymal stem cells
- newly diagnosed
- cardiac arrest
- radiation therapy
- bone marrow
- candida albicans
- cell therapy
- prognostic factors
- lymph node
- patient reported
- clinical practice
- acute respiratory distress syndrome
- neoadjuvant chemotherapy
- respiratory failure