A Histone Deacetylase Inhibitor Induces Acetyl-CoA Depletion Leading to Lethal Metabolic Stress in RAS-Pathway Activated Cells.

Agnes Basseville Pierre-Christian Violet Maryam SafariCarole SourbierW Marston LinehanRobert W RobeyMark LevineDan L SackettSusan E Bates

Published in: Cancers (2022)

Our study reveals the importance of acetyl-CoA metabolism in HDAC sensitivity, and it highlights acetyl-CoA generation pathways as potential targets to combine with HDACi.

Keyphrases

histone deacetylase
fatty acid
induced apoptosis
cell cycle arrest
oxidative stress
cell death
risk assessment
stress induced
wild type
cell proliferation
human health
pi k akt