Human pegivirus (HPgV) infection in sub-Saharan Africa-A call for a renewed research agenda.
Shivank SinghJason Tory BlackardPublished in: Reviews in medical virology (2017)
The human pegivirus (HPgV)-formerly GB virus C-has a beneficial impact on HIV disease progression that has been described in multiple studies. Given the high prevalence of HIV in sub-Saharan Africa and the continuing need to suppress HIV replication, this review provides a comprehensive overview of the existing data on HPgV infection in sub-Saharan Africa, with a particular focus on studies of prevalence and the circulating HPgV genotypes. This review also highlights the need for additional studies of HPgV conducted on the African continent and proposes a research agenda for evaluation of HPgV.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv testing
- hiv infected
- human immunodeficiency virus
- endothelial cells
- hepatitis c virus
- hiv aids
- men who have sex with men
- case control
- induced pluripotent stem cells
- pluripotent stem cells
- south africa
- risk factors
- public health
- machine learning
- big data
- data analysis
- deep learning
- medical education