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RNA-sequencing analysis reveals the potential molecular mechanism of RAD54B in the proliferation of inflamed human dental pulp cells.

Pei HuangFushi WangXinhuan WangXiujiao MengWeiwei QiaoLiuyan Meng
Published in: International endodontic journal (2022)
Gene expression profiles of normal, carious and pulpitic human dental pulp tissues were revealed. HRR components were elucidated to function in dental pulp inflammation. Amongst the DEGs in HRR, RAD54B regulated the proliferation of inflamed hDPCs via P53/P21 signalling. This research deepens our understanding of dental pulp inflammation and provides new insight to clarify the underlying mechanisms.
Keyphrases
  • endothelial cells
  • oxidative stress
  • dna damage
  • single cell
  • signaling pathway
  • induced apoptosis
  • induced pluripotent stem cells
  • dna repair
  • pluripotent stem cells
  • gene expression
  • cell proliferation
  • cell death