A Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma.

Juanita LopezJulia Lai-KwonRhoda MolifeLiam WelshNina TunariuDesamparados RodaPaula Fernández-GarcíaVictoria LladóAdrian G McNichollCatalina A RossellóRichard J TaylorAnalía AzaroJordi Rodon AhnertJulieann SluddenGareth J VealRuth PlummerAnder UrruticoecheaAinhara LahuertaKarmele MujikaPablo V Escribá

Published in: British journal of cancer (2023)

EudraCT registration number: 2012-001527-13; Clinicaltrials.gov registration number: NCT01792310.

Keyphrases

single cell
cell death
study protocol
cell therapy
clinical trial
phase iii
endoplasmic reticulum stress
signaling pathway
transcription factor
phase ii
randomized controlled trial
stem cells
mesenchymal stem cells
bone marrow